Tetraethylammonium chloride
Tetraethylammonium chloride
CAS: 56-34-8
Molecular Formula: C8H20ClN
Tetraethylammonium chloride - Names and Identifiers
| Name | Tetraethylammonium chloride |
| Synonyms | TEA CHLORIDE ETAMON CHLORIDE Tetraethylammonium tetraethyl-ammoniuchloride Tetraethylammonium chloride TETRAETHYLAMMONIUM CHLORIDE Tetraethyl Ammonium Chloride TETRAETHYLAMINEHYDROCHLORIDE AMMONIUM,TETRAETHYL-,CHLORIDE N,N,N-triethylethanaminium chloride TETRAETHYLAMMONIUMCHLORIDE,MONOHYDRATE,CRYSTAL,REAGENT |
| CAS | 56-34-8 |
| EINECS | 200-267-5 |
| InChI | InChI=1/C6H15N.ClH/c1-4-7(5-2)6-3;/h4-6H2,1-3H3;1H/p-1 |
| InChIKey | YMBCJWGVCUEGHA-UHFFFAOYSA-M |
Tetraethylammonium chloride - Physico-chemical Properties
| Molecular Formula | C8H20ClN |
| Molar Mass | 165.7 |
| Density | 1.08 |
| Melting Point | 39°C |
| Boling Point | 273.32°C (rough estimate) |
| Water Solubility | Soluble in water, ethanol, chloroform, or acetone |
| Solubility | Soluble in water, ethanol, chloroform and acetone, slightly soluble in benzene and ether, |
| Appearance | White solid |
| Color | white to light yellow |
| Maximum wavelength(λmax) | ['λ: 260 nm Amax: 0.03', , 'λ: 280 nm Amax: 0.03'] |
| Merck | 14,9200 |
| BRN | 3563247 |
| PH | 4.0 to 7.0(50g/L, 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. Protect from moisture. |
| Sensitive | Hygroscopic |
| Refractive Index | 1.5480 (estimate) |
| MDL | MFCD00011828 |
| Physical and Chemical Properties | Density 1.08 melting point 39°C |
| Use | Used as a polarographic analysis reagent |
| In vivo study | Tetraethylammonium (1 mM, 3 mM, and 5 mM) significantly increases the amplitude and frequency of contractility of colon and rectum from rats in longitudinal and circular direction. Tetraethylammonium at 5 mM and 15 mM concentrations shows no effect on histology of colon and rectum from rats that are administered locally with Tetraethylammonium into colon lumen from anus for 10 days. |
Tetraethylammonium chloride - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | BS6125000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 29239000 |
| Toxicity | LD50 i.v. in dogs: 55.7-72.4 mg/kg (Keith, Jr.) |
Tetraethylammonium chloride - Reference
| Reference Show more | 1. Xiaoxiao Wei, Yuzhi Wang, Jing Chen, Fangting Xu, Ziwei Liu, Xiyan He, Heqiong Li, Yigang Zhou,Adsorption of pharmaceuticals and personal care products by deep eutectic solvents-regulated magnetic metal-organic framework adsorbents: Performance and mechan 2. [IF=1.627] Yanming Xia et al."Transport mechanism of ursodeoxycholic acid in human placental BeWo cells."Biopharm Drug Dispos. 2018 Jul;39(7):335-343 3. [IF=13.273] Xiaoxiao Wei et al."Adsorption of pharmaceuticals and personal care products by deep eutectic solvents-regulated magnetic metal-organic framework adsorbents: Performance and mechanism."Chem Eng J. 2020 Jul;392:124808 |
Tetraethylammonium chloride - Introduction
Solubility in colorless crystalline water: 1410G/L (25°C). The pH of the 10% aqueous solution is 6.48, and it is heated to 95 ℃ for 28 hours without changing the pH. It's irritating.
Last Update：2022-10-16 17:26:23
Tetraethylammonium chloride - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| biological activity | tetraethlaminium chloride is a non-selective blocker of potassium channels. Tetraethlaminium chloride is a good substrate for organic cation transporters and has anti-tumor properties. |
| Cell Line: | Rat C6 and 9L glioma cells Rat C6 and 9L glioma cells Rat C6 and 9L glioma cells |
| Concentration: | 0.2 mM, 2 mM, 20 mM, 40 mM and 60 mM 40 mM 40 mM |
| Incubation Time: | 24 hours, 48 hours and 72 hours 24 hours, 48 hours and 72 hours 12 hours, 24 hours, 48 hours |
| Result: | Inhibited the proliferation of C6 and 9L cells in a dose- and time-dependent manner. Significantly increased apoptosis in cells. The expression of Bax was markedly increased, while that of Bcl-2 showed a decreasing trend 12, 24 and 48 h. |
| Use | phase transfer catalyst for polymerization. The membrane carries the electrolyte for research. Examination of antimony and bismuth, determination of gold. Polarographic analysis was used as a polarographic analysis reagent A phase transfer catalyst for polymerization. The membrane carries the electrolyte for research. Examination of antimony and bismuth, determination of gold. Polarographic analysis. Blocking K channels; Blocking acetylcholine neurotransmitters by blocking receptor-mediated K flow. |
Last Update：2024-04-10 22:29:15
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